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Research article

Cerebral organoid during development

Immune response in autism, revealed by in-vivo studies of xenotransplanted human brain organoids

Stem-cell-derived microglial cells in forebrain organoids, derived from stem cell lines from patients with ASD and macrocephaly and transplanted into the brains of mice, allowed to study in-vivo immune responses.

By Rohini Subrahmanyam

Published October 10, 2023 | Original research published in Cell | Human microglia, Brain organoids, Induced pluripotent stem cells (iPSCs), Organoid transplantation, Microglia surveillance, Xenotransplantation, Neuro-immune interactions, Microglia in vivo identity, Autism spectrum disorders


Einstein's field equations

The Point of Contention with Standard Cosmology

A rapidly growing body of high-precision cosmological data has moved beyond the standard model’s ability to explain it. A possible culprit: the set of simplistic built-in assumptions which are poorly motivated by fundamental theory.

By Fulvio Melia

Published October 6, 2023