Immune response in autism, revealed by in-vivo studies of xenotransplanted human brain organoids
Stem-cell-derived microglial cells in forebrain organoids, derived from stem cell lines from patients with ASD and macrocephaly and transplanted into the brains of mice, allowed to study in-vivo immune responses.
By Rohini Subrahmanyam
Published October 10, 2023 | Original research published in Cell | Human microglia, Brain organoids, Induced pluripotent stem cells (iPSCs), Organoid transplantation, Microglia surveillance, Xenotransplantation, Neuro-immune interactions, Microglia in vivo identity, Autism spectrum disorders